(S)-methyl 5-guanidino-2-(4-methylphenylsulfonamido)pentanoate
P-TOLUENESULFONYL-L-ARGININE METHYL ESTER HCL
CAS: 901-47-3
Molecular Formula: C14H22N4O4S
(S)-methyl 5-guanidino-2-(4-methylphenylsulfonamido)pentanoate - Names and Identifiers
(S)-methyl 5-guanidino-2-(4-methylphenylsulfonamido)pentanoate - Physico-chemical Properties
| Molecular Formula | C14H22N4O4S |
| Molar Mass | 342.41 |
| Density | 1.34 |
| Storage Condition | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
| In vitro study | The absence of APC substrates, TAME ejects Cdc20 from the APC by promoting Cdc20 auto-ubiquitination in its N-terminal region. Cyclin B1 antagonizes TAME's effect by promoting binding of free Cdc20 to the APC and suppressing Cdc20 auto-ubiquitination. TAME stabilizes cyclin B1 in Xenopus extract by two mechanisms. First, it reduces the k cat of the APC Cdc20 /cyclin B1 complex without affecting the K m , slowing the initial ubiquitination of unmodified cyclin B1. Second, as cyclin B1 becomes ubiquitinated, it loses its ability to promote Cdc20 binding to the APC in the presence of TAME. As a result, cyclin B1 ubiquitination terminates before reaching the threshold necessary for proteolysis. |
(S)-methyl 5-guanidino-2-(4-methylphenylsulfonamido)pentanoate - Introduction
P-TOLUENESULFONYL-L-ARGININE METHYL ESTER HCL is an organic compound, commonly abbreviated as MSB. Its nature is as follows:
Appearance: White crystalline powdery solid.
Molecular formula: C14H18N4O4S
Molecular weight: 338.39g/mol
Melting Point: 176-178 ℃
Solubility: Soluble in water and ethanol.
P-TOLUENESULFONYL-L-ARGININE METHYL ESTER HCL main uses are as follows:
1. Inhibitors in bioassays: They can inhibit the activity of some proteases and are used in biological and biochemical research.
2. Application of proteomics: used as a protective agent for protein sample pretreatment.
3. Intermediates in chemical synthesis: can be used as intermediates in the synthesis of peptides and drugs.
The method of preparing P-TOLUENESULFONYL-L-ARGININE METHYL ESTER HCL is relatively complicated and generally needs to be completed by chemical synthesis.
Regarding safety information, according to the chemical structure of MSB, it is generally considered to be relatively safe under appropriate operating and storage conditions. However, as a chemical, the following safety matters should be paid attention to during operation:
1. Avoid direct contact with the skin, use should wear protective gloves and safety glasses.
2. Avoid inhalation of dust, use should wear a mask.
3. Avoid swallowing. If swallowed, seek medical attention immediately.
In addition, the use and handling specifications of the relevant chemicals should be followed on a case-by-case basis to ensure the safe use and handling of the compound.
Appearance: White crystalline powdery solid.
Molecular formula: C14H18N4O4S
Molecular weight: 338.39g/mol
Melting Point: 176-178 ℃
Solubility: Soluble in water and ethanol.
P-TOLUENESULFONYL-L-ARGININE METHYL ESTER HCL main uses are as follows:
1. Inhibitors in bioassays: They can inhibit the activity of some proteases and are used in biological and biochemical research.
2. Application of proteomics: used as a protective agent for protein sample pretreatment.
3. Intermediates in chemical synthesis: can be used as intermediates in the synthesis of peptides and drugs.
The method of preparing P-TOLUENESULFONYL-L-ARGININE METHYL ESTER HCL is relatively complicated and generally needs to be completed by chemical synthesis.
Regarding safety information, according to the chemical structure of MSB, it is generally considered to be relatively safe under appropriate operating and storage conditions. However, as a chemical, the following safety matters should be paid attention to during operation:
1. Avoid direct contact with the skin, use should wear protective gloves and safety glasses.
2. Avoid inhalation of dust, use should wear a mask.
3. Avoid swallowing. If swallowed, seek medical attention immediately.
In addition, the use and handling specifications of the relevant chemicals should be followed on a case-by-case basis to ensure the safe use and handling of the compound.
Last Update：2024-04-09 20:52:54
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Mobile: 18021002903
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